Assay Detail
Binding
CHEMBL4003699
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Inhibition of Aurora A (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.26 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062453 | — | — | 1 | 5.28 |
| CHEMBL4063211 | — | — | 1 | 5.24 |
| CHEMBL4091089 | — | — | 1 | - |
| CHEMBL4087758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062453 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4063211 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4091089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4087758 | — | IC50 | > | 10000.0 | nM | - |