Assay Detail
Binding
CHEMBL4003769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.47 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078898 | — | — | 2 | 8.22 |
| CHEMBL4094492 | — | — | 2 | 8.15 |
| CHEMBL4066861 | — | — | 1 | 7.96 |
| CHEMBL4082309 | — | — | 1 | 7.85 |
| CHEMBL4088144 | — | — | 1 | 7.80 |
| CHEMBL4067013 | — | — | 1 | 7.77 |
| CHEMBL4073318 | — | — | 1 | 7.58 |
| CHEMBL4104657 | — | — | 1 | 7.58 |
| CHEMBL4064123 | — | — | 1 | 7.58 |
| CHEMBL4102101 | — | — | 1 | 7.55 |
| CHEMBL4091876 | — | — | 1 | 7.47 |
| CHEMBL4084116 | — | — | 1 | 7.04 |
| CHEMBL367625 | — | — | 1 | 6.96 |
| CHEMBL4104505 | — | — | 1 | 6.92 |
| CHEMBL4100324 | — | — | 1 | 6.79 |
| CHEMBL4080283 | — | — | 1 | 6.72 |
| CHEMBL1532768 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078898 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4094492 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4066861 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4094492 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4082309 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4078898 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4088144 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4067013 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4104657 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4073318 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4064123 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4102101 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4091876 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4084116 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL367625 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4104505 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4100324 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4080283 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1532768 | — | IC50 | = | 498.0 | nM | 6.30 |