Assay Detail
Functional
CHEMBL4004006
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Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH5.2 cells after 72 hrs by luciferase reporter gene assay
28
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.02 | 6.10 |
| EC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061193 | — | — | 1 | 6.10 |
| CHEMBL4062449 | — | — | 2 | 5.39 |
| CHEMBL4080897 | — | — | 2 | 5.37 |
| CHEMBL4089519 | — | — | 2 | 5.33 |
| CHEMBL4099643 | — | — | 2 | 5.23 |
| CHEMBL459515 | — | — | 1 | 5.11 |
| CHEMBL4082614 | — | — | 2 | 4.79 |
| CHEMBL4071088 | — | — | 4 | 4.69 |
| CHEMBL4101377 | — | — | 2 | 4.65 |
| CHEMBL4061362 | — | — | 2 | 4.57 |
| CHEMBL1486698 | — | — | 2 | 4.55 |
| CHEMBL4087348 | — | — | 2 | - |
| CHEMBL4060204 | — | — | 2 | - |
| CHEMBL4062272 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061193 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4062449 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4080897 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4089519 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4099643 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL459515 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4082614 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4071088 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4101377 | — | EC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4061362 | — | EC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL1486698 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4071088 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4087348 | — | EC50 | = | 146800.0 | nM | - |
| CHEMBL4060204 | — | EC50 | > | 255400.0 | nM | - |
| CHEMBL4062272 | — | EC50 | = | 234600.0 | nM | - |
| CHEMBL4071088 | — | EC90 | = | 149.0 | uM | - |
| CHEMBL4071088 | — | EC90 | = | 61.7 | uM | - |
| CHEMBL4062449 | — | EC90 | = | 12.4 | uM | - |
| CHEMBL4061362 | — | EC90 | = | 100.0 | uM | - |
| CHEMBL4089519 | — | EC90 | = | 14.0 | uM | - |
| CHEMBL4099643 | — | EC90 | = | 21.6 | uM | - |
| CHEMBL4080897 | — | EC90 | = | 11.6 | uM | - |
| CHEMBL4082614 | — | EC90 | = | 61.7 | uM | - |
| CHEMBL4101377 | — | EC90 | = | 81.1 | uM | - |
| CHEMBL4087348 | — | EC90 | > | 206.2 | uM | - |
| CHEMBL4060204 | — | EC90 | > | 255.4 | uM | - |
| CHEMBL4062272 | — | EC90 | > | 264.2 | uM | - |
| CHEMBL1486698 | — | EC90 | = | 97.6 | uM | - |