Assay Detail
Binding
CHEMBL4004009
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Inhibition of Hepatitis C virus genotype 1b NS3 helicase unwinding activity using fluorescent DNA substrate by molecular beacon assay
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.76 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 6.52 |
| CHEMBL3974381 | — | — | 1 | 5.00 |
| CHEMBL4071088 | — | — | 2 | - |
| CHEMBL4062449 | — | — | 1 | - |
| CHEMBL4061362 | — | — | 1 | - |
| CHEMBL4089519 | — | — | 1 | - |
| CHEMBL4099643 | — | — | 1 | - |
| CHEMBL4080897 | — | — | 1 | - |
| CHEMBL4082614 | — | — | 1 | - |
| CHEMBL4101377 | — | — | 1 | - |
| CHEMBL4061193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3974381 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4071088 | — | IC50 | - | — | - | |
| CHEMBL4071088 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4062449 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4061362 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4089519 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4099643 | — | IC50 | = | 438000.0 | nM | - |
| CHEMBL4080897 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4082614 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4101377 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4061193 | — | IC50 | > | 1000000.0 | nM | - |