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Assay Detail

CHEMBL4004375

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectrophotometric method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carboxylic ester hydrolase (CHEMBL4105977)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies.
Singh H, Singh JV, Gupta MK, Singh P, Sharma S, Nepali K, Bedi PMS.
Bioorg Med Chem Lett (2017) 27 : 850 -854
PubMed 28117203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 7.80 9.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4084903 1 9.11
CHEMBL4102852 1 8.85
CHEMBL4092661 1 8.70
CHEMBL361608 1 8.49
CHEMBL436080 1 8.28
CHEMBL4083931 1 8.17
CHEMBL368236 1 8.16
CHEMBL4099439 1 7.96
CHEMBL4069506 1 7.96
CHEMBL4062213 1 7.85
CHEMBL4096846 1 7.79
CHEMBL359819 1 7.70
CHEMBL177059 1 7.60
CHEMBL4086963 1 7.58
CHEMBL4078823 1 7.54
CHEMBL4081273 1 7.52
CHEMBL4063269 1 7.47
CHEMBL179925 1 7.43
CHEMBL4097350 1 7.41
CHEMBL4070170 1 7.41
CHEMBL4093364 1 7.41
CHEMBL4067460 1 7.41
CHEMBL4073942 1 7.40
CHEMBL4080830 1 7.38
CHEMBL4088699 1 7.37
CHEMBL4102088 1 7.37
CHEMBL283196 ALPHA-NAPHTHOFLAVONE 1 7.32
CHEMBL1951839 1 -
CHEMBL4073172 1 -
CHEMBL4093856 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4084903 IC50 = 0.78 nM 9.11
CHEMBL4102852 IC50 = 1.43 nM 8.85
CHEMBL4092661 IC50 = 1.99 nM 8.70
CHEMBL361608 IC50 = 3.22 nM 8.49
CHEMBL436080 IC50 = 5.24 nM 8.28
CHEMBL4083931 IC50 = 6.81 nM 8.17
CHEMBL368236 IC50 = 6.99 nM 8.16
CHEMBL4099439 IC50 = 11.01 nM 7.96
CHEMBL4069506 IC50 = 10.85 nM 7.96
CHEMBL4062213 IC50 = 14.08 nM 7.85
CHEMBL4096846 IC50 = 16.12 nM 7.79
CHEMBL359819 IC50 = 20.1 nM 7.70
CHEMBL177059 IC50 = 25.14 nM 7.60
CHEMBL4086963 IC50 = 26.09 nM 7.58
CHEMBL4078823 IC50 = 28.51 nM 7.54
CHEMBL4081273 IC50 = 30.04 nM 7.52
CHEMBL4063269 IC50 = 34.15 nM 7.47
CHEMBL179925 IC50 = 37.33 nM 7.43
CHEMBL4067460 IC50 = 39.23 nM 7.41
CHEMBL4093364 IC50 = 39.08 nM 7.41
CHEMBL4097350 IC50 = 38.89 nM 7.41
CHEMBL4070170 IC50 = 38.98 nM 7.41
CHEMBL4073942 IC50 = 40.03 nM 7.40
CHEMBL4080830 IC50 = 41.28 nM 7.38
CHEMBL4088699 IC50 = 43.03 nM 7.37
CHEMBL4102088 IC50 = 42.99 nM 7.37
CHEMBL283196 ALPHA-NAPHTHOFLAVONE IC50 = 47.8 nM 7.32
CHEMBL2420082 IC50 - -
CHEMBL2420083 IC50 - -
CHEMBL4092791 IC50 - -
CHEMBL4061237 IC50 - -
CHEMBL4065755 IC50 - -
CHEMBL4097793 IC50 - -
CHEMBL4070661 IC50 - -
CHEMBL4064195 IC50 - -
CHEMBL4085756 IC50 - -
CHEMBL4061501 IC50 - -
CHEMBL4093856 IC50 - -
CHEMBL4073172 IC50 - -
CHEMBL1951839 IC50 - -