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Assay Detail

CHEMBL4004465

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Functional
Antiproliferative activity against mouse 4T1 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type 4T1
Confidence 1 — Organism
Curated By Autocuration

Target

4T1 (CHEMBL612589)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological evaluation of 2-alkoxycarbonylallyl esters as potential anticancer agents.
Ronayne CT, Solano LN, Nelson GL, Lueth EA, Hubbard SL, Schumacher TJ, Gardner ZS, Jonnalagadda SK, Gurrapu S, Holy J, Mereddy VR.
Bioorg Med Chem Lett (2017) 27 : 776 -780
PubMed 28129978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.68 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4087388 1 5.36
CHEMBL4103764 1 5.26
CHEMBL4094376 1 4.87
CHEMBL4095300 1 4.87
CHEMBL4079511 1 4.83
CHEMBL4103056 1 4.77
CHEMBL4073788 1 4.72
CHEMBL4065192 1 4.71
CHEMBL4086632 1 4.66
CHEMBL1255721 METHYL BROMOMETHYL ACRYLATE 1 4.65
CHEMBL4088282 1 4.65
CHEMBL4081923 1 4.64
CHEMBL3741392 1 4.61
CHEMBL4099631 1 4.61
CHEMBL4067890 1 4.60
CHEMBL4072744 1 4.58
CHEMBL4080430 1 4.53
CHEMBL4068701 1 4.44
CHEMBL4060046 1 4.37
CHEMBL4065988 1 4.30
CHEMBL4096017 1 4.28
CHEMBL350488 1 -
CHEMBL515 CHLORAMBUCIL 4.0 1 -
CHEMBL4098449 1 -
CHEMBL4078776 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4087388 IC50 = 4360.0 nM 5.36
CHEMBL4103764 IC50 = 5510.0 nM 5.26
CHEMBL4094376 IC50 = 13360.0 nM 4.87
CHEMBL4095300 IC50 = 13360.0 nM 4.87
CHEMBL4079511 IC50 = 14750.0 nM 4.83
CHEMBL4103056 IC50 = 16840.0 nM 4.77
CHEMBL4073788 IC50 = 18920.0 nM 4.72
CHEMBL4065192 IC50 = 19360.0 nM 4.71
CHEMBL4086632 IC50 = 21960.0 nM 4.66
CHEMBL1255721 METHYL BROMOMETHYL ACRYLATE IC50 = 22380.0 nM 4.65
CHEMBL4088282 IC50 = 22500.0 nM 4.65
CHEMBL4081923 IC50 = 22960.0 nM 4.64
CHEMBL3741392 IC50 = 24700.0 nM 4.61
CHEMBL4099631 IC50 = 24530.0 nM 4.61
CHEMBL4067890 IC50 = 25120.0 nM 4.60
CHEMBL4072744 IC50 = 25990.0 nM 4.58
CHEMBL4080430 IC50 = 29530.0 nM 4.53
CHEMBL4068701 IC50 = 36000.0 nM 4.44
CHEMBL4060046 IC50 = 43130.0 nM 4.37
CHEMBL4065988 IC50 = 49810.0 nM 4.30
CHEMBL4096017 IC50 = 52330.0 nM 4.28
CHEMBL350488 IC50 > 100000.0 nM -
CHEMBL515 CHLORAMBUCIL IC50 > 100000.0 nM -
CHEMBL4098449 IC50 > 100000.0 nM -
CHEMBL4078776 IC50 > 100000.0 nM -