Assay Detail
Binding
CHEMBL4004491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.49 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.10 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.15 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.86 |
| CHEMBL4104567 | — | — | 1 | 5.36 |
| CHEMBL4103010 | — | — | 1 | 5.20 |
| CHEMBL4074119 | — | — | 1 | 5.17 |
| CHEMBL4062746 | — | — | 1 | 5.14 |
| CHEMBL4084286 | — | — | 1 | 5.07 |
| CHEMBL4100880 | — | — | 1 | 4.82 |
| CHEMBL4081930 | — | — | 1 | 4.80 |
| CHEMBL4099927 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL887 | RASAGILINE | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4104567 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4103010 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4074119 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4062746 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL4084286 | — | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL4100880 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4081930 | — | IC50 | = | 15650.0 | nM | 4.80 |
| CHEMBL4099927 | — | IC50 | = | 19320.0 | nM | 4.71 |