Assay Detail
Binding
CHEMBL4004492
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Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.30 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.36 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.37 |
| CHEMBL4074119 | — | — | 1 | 5.36 |
| CHEMBL4103010 | — | — | 1 | 5.28 |
| CHEMBL4084286 | — | — | 1 | 5.21 |
| CHEMBL4100880 | — | — | 1 | 5.12 |
| CHEMBL4081930 | — | — | 1 | 5.09 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.05 |
| CHEMBL4099927 | — | — | 1 | 4.89 |
| CHEMBL4062746 | — | — | 1 | 4.87 |
| CHEMBL4104567 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4074119 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4103010 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4084286 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4100880 | — | IC50 | = | 7590.0 | nM | 5.12 |
| CHEMBL4081930 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL4099927 | — | IC50 | = | 12860.0 | nM | 4.89 |
| CHEMBL4062746 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL4104567 | — | IC50 | = | 21500.0 | nM | 4.67 |