Assay Detail
Binding
CHEMBL4004499
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Inhibition of Kv1.5 (unknown origin)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 5 (CHEMBL4306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.87 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065169 | — | — | 1 | 8.05 |
| CHEMBL4085436 | — | — | 1 | 7.64 |
| CHEMBL4105245 | — | — | 1 | 7.58 |
| CHEMBL4104525 | — | — | 1 | 7.54 |
| CHEMBL4062996 | — | — | 1 | 7.52 |
| CHEMBL4075394 | — | — | 1 | 7.48 |
| CHEMBL4095750 | — | — | 1 | 7.39 |
| CHEMBL4088894 | — | — | 1 | 7.25 |
| CHEMBL4067665 | — | — | 1 | 7.21 |
| CHEMBL4100226 | — | — | 1 | 7.19 |
| CHEMBL4097667 | — | — | 1 | 7.19 |
| CHEMBL4100098 | — | — | 1 | 7.08 |
| CHEMBL4094177 | — | — | 1 | 7.08 |
| CHEMBL4080304 | — | — | 1 | 7.05 |
| CHEMBL4097545 | — | — | 1 | 6.96 |
| CHEMBL4094185 | — | — | 1 | 6.94 |
| CHEMBL4079636 | — | — | 1 | 6.88 |
| CHEMBL4068841 | — | — | 1 | 6.87 |
| CHEMBL4072707 | — | — | 1 | 6.86 |
| CHEMBL4081003 | — | — | 1 | 6.83 |
| CHEMBL4102309 | — | — | 1 | 6.82 |
| CHEMBL4080956 | — | — | 1 | 6.79 |
| CHEMBL4061731 | — | — | 1 | 6.77 |
| CHEMBL4084347 | — | — | 1 | 6.71 |
| CHEMBL4074029 | — | — | 1 | 6.63 |
| CHEMBL4094570 | — | — | 1 | 6.56 |
| CHEMBL4089812 | — | — | 1 | 6.55 |
| CHEMBL4076764 | — | — | 1 | 6.54 |
| CHEMBL4087512 | — | — | 1 | 6.35 |
| CHEMBL4105373 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065169 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4085436 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4105245 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4104525 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4062996 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4075394 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4095750 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4088894 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4067665 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4097667 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4100226 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4100098 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4094177 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4080304 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4097545 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4094185 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4079636 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4068841 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4072707 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4081003 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4102309 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4080956 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4061731 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4084347 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4074029 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4094570 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4089812 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL4076764 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4087512 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL4105373 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL4074093 | — | IC50 | = | 1276.0 | nM | 5.89 |
| CHEMBL4089937 | — | IC50 | = | 1386.0 | nM | 5.86 |
| CHEMBL4060189 | — | IC50 | = | 1592.0 | nM | 5.80 |
| CHEMBL4098469 | — | IC50 | = | 2865.0 | nM | 5.54 |
| CHEMBL4096382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075240 | — | IC50 | > | 10000.0 | nM | - |