Assay Detail
Binding
CHEMBL4004506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kv4.3 (unknown origin) assessed as reduction in transient outward potassium current by high throughput clamp method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A-type voltage-gated potassium channel KCND3 (CHEMBL1964) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.36 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065169 | — | — | 1 | 5.64 |
| CHEMBL4104525 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065169 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4104525 | — | IC50 | = | 8300.0 | nM | 5.08 |