Assay Detail
Functional
CHEMBL4004559
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Inhibition of human PBMC proliferation assessed as decrease in [3H]-TdR uptake after 6 days by mixed lymphocyte reaction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.00 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 7.55 |
| CHEMBL4064291 | — | — | 1 | 7.27 |
| CHEMBL4085837 | — | — | 1 | 7.23 |
| CHEMBL4077967 | — | — | 1 | 6.56 |
| CHEMBL4102228 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4064291 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4085837 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4077967 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL4102228 | — | IC50 | = | 406.0 | nM | 6.39 |