Assay Detail
Binding
CHEMBL4004560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKCbeta in mouse B cells assessed as reduction in IgM-stimulated cell proliferation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.58 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 6.63 |
| CHEMBL4077967 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4077967 | — | IC50 | = | 296.0 | nM | 6.53 |