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Assay Detail

CHEMBL4004946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MDA-MB-231 cells after 72 hrs by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.
Nyandoro SS, Munissi JJ, Gruhonjic A, Duffy S, Pan F, Puttreddy R, Holleran JP, Fitzpatrick PA, Pelletier J, Avery VM, Rissanen K, Erdélyi M.
J Nat Prod (2017) 80 : 114 -125
PubMed 28001067 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.39 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4076187 1 7.52
CHEMBL4104688 1 7.05
CHEMBL4078002 1 6.92
CHEMBL4067046 1 6.62
CHEMBL4062020 1 6.54
CHEMBL4083758 1 6.54
CHEMBL4096044 1 6.35
CHEMBL4085875 1 5.68
CHEMBL4080462 1 5.57
CHEMBL243816 3-HYDROXYBENZALDEHYDE 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4076187 IC50 = 30.0 nM 7.52
CHEMBL4104688 IC50 = 90.0 nM 7.05
CHEMBL4078002 IC50 = 120.0 nM 6.92
CHEMBL4067046 IC50 = 240.0 nM 6.62
CHEMBL4062020 IC50 = 290.0 nM 6.54
CHEMBL4083758 IC50 = 290.0 nM 6.54
CHEMBL4096044 IC50 = 450.0 nM 6.35
CHEMBL4085875 IC50 = 2100.0 nM 5.68
CHEMBL4080462 IC50 = 2700.0 nM 5.57
CHEMBL243816 3-HYDROXYBENZALDEHYDE IC50 = 8200.0 nM 5.09