Assay Detail
Binding
CHEMBL4004948
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Inhibition of CDK2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.62 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088242 | — | — | 1 | 9.10 |
| CHEMBL319467 | — | — | 1 | 8.30 |
| CHEMBL269881 | — | — | 1 | 4.77 |
| CHEMBL259244 | — | — | 1 | 4.31 |
| CHEMBL226395 | METHYLGUANINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088242 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL319467 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL269881 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL259244 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL226395 | METHYLGUANINE | IC50 | > | 100000.0 | nM | - |