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Assay Detail

CHEMBL4005233

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML.
Eur J Med Chem (2017) 127 : 250 -262
PubMed 28064079 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 6 4.64 4.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL153 TROLOX 1 4.79
CHEMBL165 RESVERATROL 3.0 1 4.59
CHEMBL600 ACETYLCYSTEINE 4.0 1 4.55
CHEMBL4066309 1 -
CHEMBL4083174 1 -
CHEMBL4081795 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL153 TROLOX EC50 = 16200.0 nM 4.79
CHEMBL165 RESVERATROL EC50 = 25600.0 nM 4.59
CHEMBL600 ACETYLCYSTEINE EC50 = 28000.0 nM 4.55
CHEMBL4066309 EC50 > 5000000.0 nM -
CHEMBL4083174 EC50 = 155000.0 nM -
CHEMBL4081795 EC50 > 5000000.0 nM -