Assay Detail
Binding
CHEMBL4005287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-iloprost from recombinant dog IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.37 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.77 |
| CHEMBL3933704 | — | — | 1 | 6.74 |
| CHEMBL3301604 | RALINEPAG | 3.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3933704 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL3301604 | RALINEPAG | Ki | = | 256.0 | nM | 6.59 |