Assay Detail
Functional
CHEMBL4005443
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.77 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.05 |
| CHEMBL4094853 | — | — | 1 | 6.58 |
| CHEMBL4065754 | — | — | 1 | 5.24 |
| CHEMBL481839 | ESCHOLTZINE | — | 1 | 4.58 |
| CHEMBL4103555 | — | — | 1 | 4.39 |
| CHEMBL4079286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.82 | nM | 8.05 |
| CHEMBL4094853 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4065754 | — | IC50 | = | 5707.0 | nM | 5.24 |
| CHEMBL481839 | ESCHOLTZINE | IC50 | = | 26130.0 | nM | 4.58 |
| CHEMBL4103555 | — | IC50 | = | 41010.0 | nM | 4.39 |
| CHEMBL4079286 | — | IC50 | > | 40000.0 | nM | - |