Assay Detail
Functional
CHEMBL4005445
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Antiproliferative activity against human KB cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.86 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL4094853 | — | — | 1 | 6.64 |
| CHEMBL4065754 | — | — | 1 | 5.26 |
| CHEMBL481839 | ESCHOLTZINE | — | 1 | 4.77 |
| CHEMBL4103555 | — | — | 1 | 4.45 |
| CHEMBL4079286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL4094853 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL4065754 | — | IC50 | = | 5488.0 | nM | 5.26 |
| CHEMBL481839 | ESCHOLTZINE | IC50 | = | 17030.0 | nM | 4.77 |
| CHEMBL4103555 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL4079286 | — | IC50 | > | 40000.0 | nM | - |