Assay Detail
Functional
CHEMBL4005446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KBVIN cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBVIN |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.57 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094853 | — | — | 1 | 6.62 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.71 |
| CHEMBL4065754 | — | — | 1 | 5.23 |
| CHEMBL481839 | ESCHOLTZINE | — | 1 | 4.70 |
| CHEMBL4103555 | — | — | 1 | - |
| CHEMBL4079286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094853 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1926.0 | nM | 5.71 |
| CHEMBL4065754 | — | IC50 | = | 5907.0 | nM | 5.23 |
| CHEMBL481839 | ESCHOLTZINE | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4103555 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4079286 | — | IC50 | > | 40000.0 | nM | - |