Assay Detail
Functional
CHEMBL4005533
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Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing M2 proton channel S31N mutant infected in MDCK cells assessed as reduction in cytopathic effect after 48 hrs by crystal violet staining-based microscopic analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.70 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.57 |
| CHEMBL1172027 | — | — | 1 | 6.48 |
| CHEMBL1170181 | — | — | 1 | 6.47 |
| CHEMBL1170182 | — | — | 1 | 6.47 |
| CHEMBL295380 | — | — | 1 | 6.47 |
| CHEMBL1170792 | — | — | 1 | 6.38 |
| CHEMBL45505 | — | — | 1 | 6.05 |
| CHEMBL326069 | — | — | 1 | 5.41 |
| CHEMBL4104173 | — | — | 1 | 5.21 |
| CHEMBL4074573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL660 | AMANTADINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1172027 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1170181 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1170182 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL295380 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1170792 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL45505 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL326069 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL4104173 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL4074573 | — | IC50 | - | — | - |