Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4006076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC method
17
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-galactoside alpha-2,6-sialyltransferase 1 (CHEMBL3596075)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide.
Guo J, Li W, Xue W, Ye XS.
J Med Chem (2017) 60 : 2135 -2141
PubMed 28165727 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.90 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4065191 2 7.80
CHEMBL4102509 1 7.72
CHEMBL4091389 2 7.70
CHEMBL3629696 2 7.55
CHEMBL3629698 2 7.54
CHEMBL4063545 2 7.22
CHEMBL4097206 2 6.97
CHEMBL4081024 2 6.70
CHEMBL4083608 1 6.65
CHEMBL3629689 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4065191 Ki = 16.0 nM 7.80
CHEMBL4102509 Ki = 19.0 nM 7.72
CHEMBL4091389 Ki = 20.0 nM 7.70
CHEMBL3629696 Ki = 28.0 nM 7.55
CHEMBL3629698 Ki = 29.0 nM 7.54
CHEMBL4091389 Ki = 45.0 nM 7.35
CHEMBL4063545 Ki = 60.0 nM 7.22
CHEMBL4097206 Ki = 106.0 nM 6.97
CHEMBL4097206 Ki = 122.0 nM 6.91
CHEMBL4063545 Ki = 165.0 nM 6.78
CHEMBL4065191 Ki = 174.0 nM 6.76
CHEMBL4081024 Ki = 200.0 nM 6.70
CHEMBL4083608 Ki = 224.0 nM 6.65
CHEMBL3629696 Ki = 477.0 nM 6.32
CHEMBL3629698 Ki = 690.0 nM 6.16
CHEMBL4081024 Ki = 1000.0 nM 6.00
CHEMBL3629689 Ki = 5852.0 nM 5.23