Assay Detail
Binding
CHEMBL4006613
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Inhibition of RNase H activity of full length HIV reverse transcriptase using RNA-DNA duplex HTS-1 substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.45 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079480 | — | — | 1 | 5.96 |
| CHEMBL4100350 | — | — | 1 | 5.77 |
| CHEMBL4064119 | — | — | 1 | 5.68 |
| CHEMBL4102096 | — | — | 1 | 5.66 |
| CHEMBL4095984 | — | — | 1 | 5.57 |
| CHEMBL4091873 | — | — | 1 | 5.51 |
| CHEMBL4073756 | — | — | 1 | 5.41 |
| CHEMBL4084111 | — | — | 1 | 5.34 |
| CHEMBL4095043 | — | — | 1 | 5.28 |
| CHEMBL4068668 | — | — | 1 | 5.26 |
| CHEMBL4103727 | — | — | 1 | 5.24 |
| CHEMBL4094347 | — | — | 1 | 5.12 |
| CHEMBL4073514 | — | — | 1 | 5.00 |
| CHEMBL436546 | — | — | 1 | - |
| CHEMBL4065165 | — | — | 1 | - |
| CHEMBL4098705 | — | — | 1 | - |
| CHEMBL4080663 | — | — | 1 | - |
| CHEMBL4101420 | — | — | 1 | - |
| CHEMBL4074733 | — | — | 1 | - |
| CHEMBL4093701 | — | — | 1 | - |
| CHEMBL4066126 | — | — | 1 | - |
| CHEMBL4071987 | — | — | 1 | - |
| CHEMBL4092759 | — | — | 1 | - |
| CHEMBL4063363 | — | — | 1 | - |
| CHEMBL4085004 | — | — | 1 | - |
| CHEMBL4090318 | — | — | 1 | - |
| CHEMBL4062311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079480 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4100350 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4064119 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4102096 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4095984 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4091873 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4073756 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4084111 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4095043 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4068668 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4103727 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4094347 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4073514 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL436546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4065165 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4101420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074733 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4093701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4066126 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4071987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092759 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062311 | — | IC50 | > | 10000.0 | nM | - |