Assay Detail
Binding
CHEMBL4006614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV reverse transcriptase polymerase activity assessed as reduction in dNTP incorporation using 100 nucleotide DNA/18 nucleotide DNA as template/primer measured after 30 mins
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.72 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065165 | — | — | 1 | 7.07 |
| CHEMBL4080663 | — | — | 1 | 6.66 |
| CHEMBL4098705 | — | — | 1 | 6.52 |
| CHEMBL4071987 | — | — | 1 | 6.44 |
| CHEMBL436546 | — | — | 1 | 6.38 |
| CHEMBL4095043 | — | — | 1 | 6.35 |
| CHEMBL4101420 | — | — | 1 | 6.32 |
| CHEMBL4093701 | — | — | 1 | 6.09 |
| CHEMBL4066126 | — | — | 1 | 6.09 |
| CHEMBL4103727 | — | — | 1 | 5.82 |
| CHEMBL4074733 | — | — | 1 | 5.82 |
| CHEMBL4068668 | — | — | 1 | 5.64 |
| CHEMBL4079480 | — | — | 1 | 5.19 |
| CHEMBL4064119 | — | — | 1 | 5.19 |
| CHEMBL4092759 | — | — | 1 | 5.17 |
| CHEMBL4073514 | — | — | 1 | 5.16 |
| CHEMBL4063363 | — | — | 1 | 5.00 |
| CHEMBL4085004 | — | — | 1 | 5.00 |
| CHEMBL4090318 | — | — | 1 | 5.00 |
| CHEMBL4095984 | — | — | 1 | 5.00 |
| CHEMBL4094347 | — | — | 1 | 5.00 |
| CHEMBL4084111 | — | — | 1 | 5.00 |
| CHEMBL4073756 | — | — | 1 | - |
| CHEMBL4102096 | — | — | 1 | - |
| CHEMBL4091873 | — | — | 1 | - |
| CHEMBL4100350 | — | — | 1 | - |
| CHEMBL4062311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065165 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4080663 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4098705 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4071987 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL436546 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4095043 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4101420 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4093701 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4066126 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4103727 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4074733 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4068668 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4079480 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4064119 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4092759 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4073514 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4063363 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4085004 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4090318 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4095984 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4094347 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4084111 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4073756 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4102096 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091873 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4100350 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062311 | — | IC50 | > | 10000.0 | nM | - |