Assay Detail
Functional
CHEMBL4007111
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Antiproliferative activity against human Pfeiffer cells after 10 days by celltiter-glo luminescent cell viability Assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Pfeiffer |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.41 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060827 | — | — | 1 | 7.48 |
| CHEMBL4077363 | — | — | 1 | 7.19 |
| CHEMBL4093096 | — | — | 1 | 7.16 |
| CHEMBL4065766 | — | — | 1 | 7.01 |
| CHEMBL4076017 | — | — | 1 | 6.89 |
| CHEMBL4080018 | — | — | 1 | 5.96 |
| CHEMBL4095605 | — | — | 1 | 5.48 |
| CHEMBL4085428 | — | — | 1 | 5.48 |
| CHEMBL4075197 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060827 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4077363 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4093096 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4065766 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4076017 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4080018 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4095605 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4085428 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4075197 | — | IC50 | = | 9500.0 | nM | 5.02 |