Assay Detail
Functional
CHEMBL4007134
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Cytotoxicity against human U251 cells assessed as decrease in cell proliferation after 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 3.44 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391414 | — | — | 1 | 4.30 |
| CHEMBL2349385 | (2-PHENYL-1H-INDOL-3-YL)METHANOL | — | 1 | 3.89 |
| CHEMBL1904177 | — | — | 1 | 3.85 |
| CHEMBL4084900 | — | — | 1 | 3.60 |
| CHEMBL446452 | ARUNDINE | 3.0 | 1 | 3.55 |
| CHEMBL155625 | INDOLE-3-CARBINOL | 2.0 | 1 | 3.41 |
| CHEMBL1359077 | — | — | 1 | 3.22 |
| CHEMBL226545 | TRYPTOPHOL | — | 1 | 2.91 |
| CHEMBL3358210 | — | — | 1 | 2.91 |
| CHEMBL1320312 | — | — | 1 | 2.75 |
| CHEMBL75756 | 2-PHENYL-1H-INDOLE | — | 1 | - |
| CHEMBL15844 | INDOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391414 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2349385 | (2-PHENYL-1H-INDOL-3-YL)METHANOL | EC50 | = | 130000.0 | nM | 3.89 |
| CHEMBL1904177 | — | EC50 | = | 140000.0 | nM | 3.85 |
| CHEMBL4084900 | — | EC50 | = | 250000.0 | nM | 3.60 |
| CHEMBL446452 | ARUNDINE | EC50 | = | 280000.0 | nM | 3.55 |
| CHEMBL155625 | INDOLE-3-CARBINOL | EC50 | = | 390000.0 | nM | 3.41 |
| CHEMBL1359077 | — | EC50 | = | 600000.0 | nM | 3.22 |
| CHEMBL226545 | TRYPTOPHOL | EC50 | = | 1220000.0 | nM | 2.91 |
| CHEMBL3358210 | — | EC50 | = | 1240000.0 | nM | 2.91 |
| CHEMBL1320312 | — | EC50 | = | 1760000.0 | nM | 2.75 |
| CHEMBL75756 | 2-PHENYL-1H-INDOLE | EC50 | - | — | - | |
| CHEMBL15844 | INDOLE | EC50 | - | — | - |