Assay Detail
Functional
CHEMBL4007136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human IN1528 cells assessed as decrease in cell proliferation after 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IN1528 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 3.55 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084900 | — | — | 1 | 5.40 |
| CHEMBL2349385 | (2-PHENYL-1H-INDOL-3-YL)METHANOL | — | 1 | 5.00 |
| CHEMBL155625 | INDOLE-3-CARBINOL | 2.0 | 1 | 3.92 |
| CHEMBL446452 | ARUNDINE | 3.0 | 1 | 3.36 |
| CHEMBL1904177 | — | — | 1 | 3.36 |
| CHEMBL226545 | TRYPTOPHOL | — | 1 | 2.76 |
| CHEMBL3358210 | — | — | 1 | 2.40 |
| CHEMBL1320312 | — | — | 1 | 2.23 |
| CHEMBL15844 | INDOLE | — | 1 | - |
| CHEMBL75756 | 2-PHENYL-1H-INDOLE | — | 1 | - |
| CHEMBL1359077 | — | — | 1 | - |
| CHEMBL391414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084900 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2349385 | (2-PHENYL-1H-INDOL-3-YL)METHANOL | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL155625 | INDOLE-3-CARBINOL | EC50 | = | 119000.0 | nM | 3.92 |
| CHEMBL446452 | ARUNDINE | EC50 | = | 440000.0 | nM | 3.36 |
| CHEMBL1904177 | — | EC50 | = | 440000.0 | nM | 3.36 |
| CHEMBL226545 | TRYPTOPHOL | EC50 | = | 1740000.0 | nM | 2.76 |
| CHEMBL3358210 | — | EC50 | = | 3990000.0 | nM | 2.40 |
| CHEMBL1320312 | — | EC50 | = | 5820000.0 | nM | 2.23 |
| CHEMBL15844 | INDOLE | EC50 | - | — | - | |
| CHEMBL75756 | 2-PHENYL-1H-INDOLE | EC50 | - | — | - | |
| CHEMBL1359077 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL391414 | — | EC50 | = | 270000.0 | nM | - |