Assay Detail
Functional
CHEMBL4007271
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Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs in presence of salinomycin by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of salinomycin-hydroxamic acid conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.04 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067189 | — | — | 1 | 5.10 |
| CHEMBL154574 | — | — | 1 | 5.05 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 5.01 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | — | 1 | 5.01 |
| CHEMBL351337 | — | — | 1 | - |
| CHEMBL4091794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067189 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL154574 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL351337 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091794 | — | IC50 | > | 10000.0 | nM | - |