Assay Detail
Binding
CHEMBL4007592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-galactosidase in human PBMC using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.3 after 2 hrs by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110458 | MIGALASTAT | 4.0 | 1 | 7.10 |
| CHEMBL4085739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110458 | MIGALASTAT | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4085739 | — | IC50 | > | 160000.0 | nM | - |