Assay Detail
Binding
CHEMBL4007741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET (unknown origin) after 60 mins by TR-FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.02 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2006765 | — | — | 1 | 6.88 |
| CHEMBL4069365 | — | — | 1 | 6.42 |
| CHEMBL4078893 | — | — | 1 | 5.82 |
| CHEMBL4062803 | — | — | 1 | 5.53 |
| CHEMBL4066664 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2006765 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4069365 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL4078893 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4062803 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4066664 | — | IC50 | = | 3500.0 | nM | 5.46 |