Assay Detail
Binding
CHEMBL4007940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FLT3 ITD mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.00 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093614 | — | — | 1 | 9.15 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093614 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL535 | SUNITINIB | IC50 | = | 1.4 | nM | 8.85 |