Assay Detail
Binding
CHEMBL4008040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Aldosterone from MR overexpressed in human 293 cells measured after 2 hrs by Microbeta scintillation counting method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 9.54 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095917 | — | — | 1 | 10.10 |
| CHEMBL4086416 | — | — | 1 | 9.64 |
| CHEMBL4088896 | LY2623091 | 2.0 | 1 | 9.48 |
| CHEMBL4099276 | — | — | 1 | 9.40 |
| CHEMBL4063735 | — | — | 1 | 9.10 |
| CHEMBL4091539 | — | — | 1 | - |
| CHEMBL4101755 | — | — | 1 | - |
| CHEMBL4083760 | — | — | 1 | - |
| CHEMBL4068598 | — | — | 1 | - |
| CHEMBL4104314 | — | — | 1 | - |
| CHEMBL4094179 | — | — | 1 | - |
| CHEMBL4066645 | — | — | 1 | - |
| CHEMBL4067668 | — | — | 1 | - |
| CHEMBL4078561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095917 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL4086416 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4088896 | LY2623091 | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL4099276 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4063735 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL4091539 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4101755 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4083760 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4068598 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4104314 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4094179 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4066645 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4067668 | — | Ki | <= | 10.0 | nM | - |
| CHEMBL4078561 | — | Ki | <= | 10.0 | nM | - |