Assay Detail
Functional
CHEMBL4008052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 18 hrs by liquid scintillation counting
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 8.61 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092270 | — | — | 1 | 9.05 |
| CHEMBL4069159 | — | — | 1 | 9.00 |
| CHEMBL4089705 | — | — | 1 | 9.00 |
| CHEMBL4093865 | — | — | 1 | 8.89 |
| CHEMBL4097433 | — | — | 1 | 8.85 |
| CHEMBL4077302 | — | — | 1 | 8.82 |
| CHEMBL4100778 | — | — | 1 | 8.82 |
| CHEMBL4066300 | — | — | 1 | 8.82 |
| CHEMBL4070429 | — | — | 1 | 8.80 |
| CHEMBL4069135 | — | — | 1 | 8.80 |
| CHEMBL4074912 | — | — | 1 | 8.77 |
| CHEMBL4092098 | — | — | 1 | 8.77 |
| CHEMBL4085085 | — | — | 1 | 8.74 |
| CHEMBL4064284 | — | — | 1 | 8.74 |
| CHEMBL4100499 | — | — | 1 | 8.74 |
| CHEMBL4081536 | — | — | 1 | 8.74 |
| CHEMBL4084042 | — | — | 1 | 8.72 |
| CHEMBL580910 | — | — | 1 | 8.70 |
| CHEMBL1828820 | ARTEFENOMEL | 2.0 | 1 | 8.70 |
| CHEMBL4101597 | — | — | 1 | 8.70 |
| CHEMBL4104032 | — | — | 1 | 8.70 |
| CHEMBL4101516 | — | — | 1 | 8.70 |
| CHEMBL4070954 | — | — | 1 | 8.70 |
| CHEMBL4091361 | — | — | 1 | 8.68 |
| CHEMBL4063456 | — | — | 1 | 8.68 |
| CHEMBL4061808 | — | — | 1 | 8.68 |
| CHEMBL4099838 | — | — | 1 | 8.66 |
| CHEMBL4100572 | — | — | 1 | 8.64 |
| CHEMBL4078151 | — | — | 1 | 8.64 |
| CHEMBL4083579 | — | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092270 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4069159 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4089705 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4093865 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4097433 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4077302 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4100778 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4066300 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4070429 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4069135 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4074912 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4092098 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4100499 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4085085 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4064284 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4081536 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4084042 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL580910 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1828820 | ARTEFENOMEL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4101597 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4104032 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4101516 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4070954 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4061808 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4091361 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4063456 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4099838 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4100572 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4078151 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4083579 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4082552 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4071302 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4074019 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4092834 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4068615 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4091290 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4072076 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4062891 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4081835 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4070246 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4101605 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4077597 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4091806 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4073682 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4074836 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4062326 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4099546 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4092772 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4065089 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4096204 | — | IC50 | = | 9.5 | nM | 8.02 |