Assay Detail
Binding
CHEMBL4008127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PPARgamma (unknown origin) assessed as thermodynamic dissociation constant by SPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.89 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 8.92 |
| CHEMBL4073499 | — | — | 1 | 8.43 |
| CHEMBL4092600 | — | — | 1 | 8.31 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.89 |
| CHEMBL153057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4073499 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL4092600 | — | Kd | = | 4.9 | nM | 8.31 |
| CHEMBL295416 | PIRINIXIC ACID | Kd | = | 1297.3 | nM | 5.89 |
| CHEMBL153057 | — | Kd | - | — | - |