Assay Detail
Binding
CHEMBL4008129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of GAL4-fused human PPARalpa LBD expressed in human HepG2 cells after 20 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.99 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064900 | — | — | 1 | 7.41 |
| CHEMBL4073499 | — | — | 1 | 7.38 |
| CHEMBL4092600 | — | — | 1 | 7.34 |
| CHEMBL4100336 | — | — | 1 | 7.00 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064900 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4073499 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4092600 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4100336 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 1600.0 | nM | 5.80 |