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Assay Detail

CHEMBL4008456

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi N-terminal His-tagged full-length glucose-6-phosphate dehydrogenase expressed in Escherichia coli BL21(DE3) using glucose-6-phosphate as substrate in presence of NADP+ by spectrophotometric method
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets.
Vermelho AB, Capaci GR, Rodrigues IA, Cardoso VS, Mazotto AM, Supuran CT.
Bioorg Med Chem (2017) 25 : 1543 -1555
PubMed 28161253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.52 5.52
Ki 1 5.50 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL272195 EPIANDROSTERONE 2 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL272195 EPIANDROSTERONE IC50 = 3000.0 nM 5.52
CHEMBL272195 EPIANDROSTERONE Ki = 3200.0 nM 5.50