Assay Detail
Binding
CHEMBL4008461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT-3 enzyme coupled assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL3259474) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.72 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061448 | — | — | 1 | 8.51 |
| CHEMBL4074848 | — | — | 1 | 8.42 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.31 |
| CHEMBL4066091 | — | — | 1 | 8.09 |
| CHEMBL4078882 | — | — | 1 | 7.81 |
| CHEMBL4083606 | — | — | 1 | 7.59 |
| CHEMBL4101611 | — | — | 1 | 7.50 |
| CHEMBL4088492 | — | — | 1 | 7.49 |
| CHEMBL4064240 | — | — | 1 | 7.33 |
| CHEMBL4094769 | — | — | 1 | 7.30 |
| CHEMBL4087071 | — | — | 1 | 6.57 |
| CHEMBL4070645 | — | — | 1 | - |
| CHEMBL4078160 | — | — | 1 | - |
| CHEMBL4096215 | — | — | 1 | - |
| CHEMBL4086051 | — | — | 1 | - |
| CHEMBL4103975 | — | — | 1 | - |
| CHEMBL4093808 | — | — | 1 | - |
| CHEMBL4095411 | — | — | 1 | - |
| CHEMBL4101530 | — | — | 1 | - |
| CHEMBL4103162 | — | — | 1 | - |
| CHEMBL4097857 | — | — | 1 | - |
| CHEMBL4079833 | — | — | 1 | - |
| CHEMBL4089512 | — | — | 1 | - |
| CHEMBL4068350 | — | — | 1 | - |
| CHEMBL4097217 | — | — | 1 | - |
| CHEMBL4079201 | — | — | 1 | - |
| CHEMBL4104924 | — | — | 1 | - |
| CHEMBL4067311 | — | — | 1 | - |
| CHEMBL4091979 | — | — | 1 | - |
| CHEMBL4099274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061448 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4074848 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4066091 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4078882 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL4083606 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL4101611 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL4088492 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL4064240 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4094769 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL4087071 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4103975 | — | IC50 | - | — | - | |
| CHEMBL4091075 | — | IC50 | - | — | - | |
| CHEMBL4086051 | — | IC50 | - | — | - | |
| CHEMBL4096215 | — | IC50 | - | — | - | |
| CHEMBL4078160 | — | IC50 | - | — | - | |
| CHEMBL4070645 | — | IC50 | - | — | - | |
| CHEMBL4067233 | — | IC50 | - | — | - | |
| CHEMBL4070595 | — | IC50 | - | — | - | |
| CHEMBL4098820 | — | IC50 | - | — | - | |
| CHEMBL4088652 | — | IC50 | - | — | - | |
| CHEMBL4060420 | — | IC50 | - | — | - | |
| CHEMBL4068019 | — | IC50 | - | — | - | |
| CHEMBL4083283 | — | IC50 | - | — | - | |
| CHEMBL4070110 | — | IC50 | - | — | - | |
| CHEMBL4093808 | — | IC50 | - | — | - | |
| CHEMBL4095411 | — | IC50 | - | — | - | |
| CHEMBL4101530 | — | IC50 | - | — | - | |
| CHEMBL4103162 | — | IC50 | - | — | - | |
| CHEMBL4097857 | — | IC50 | - | — | - | |
| CHEMBL4079833 | — | IC50 | - | — | - | |
| CHEMBL4089512 | — | IC50 | - | — | - | |
| CHEMBL4068350 | — | IC50 | - | — | - | |
| CHEMBL4097217 | — | IC50 | - | — | - | |
| CHEMBL4079201 | — | IC50 | - | — | - | |
| CHEMBL4104924 | — | IC50 | - | — | - | |
| CHEMBL4067311 | — | IC50 | - | — | - | |
| CHEMBL4091979 | — | IC50 | - | — | - | |
| CHEMBL4099274 | — | IC50 | - | — | - |