Assay Detail
Binding
CHEMBL4008463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.20 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061448 | — | — | 1 | 8.31 |
| CHEMBL4074848 | — | — | 1 | 8.17 |
| CHEMBL4066091 | — | — | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061448 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4074848 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4066091 | — | IC50 | = | 7.8 | nM | 8.11 |