Assay Detail
Functional
CHEMBL4008740
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Agonist activity at human dopamine D2 receptor-short expressed in CHO-K1 cells assessed as reduction in adenylyl cyclase activator NKH 477 induced cAMP accumulation preincubated for 10 mins followed by NKH 477 addition by HTRF assay
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.44 | 7.98 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102620 | — | — | 1 | 7.98 |
| CHEMBL4092052 | — | — | 1 | 7.89 |
| CHEMBL4070196 | — | — | 1 | 7.89 |
| CHEMBL4069565 | — | — | 1 | 7.86 |
| CHEMBL4103339 | — | — | 1 | 7.83 |
| CHEMBL4072282 | — | — | 1 | 7.67 |
| CHEMBL4091498 | — | — | 1 | 7.40 |
| CHEMBL4071240 | — | — | 1 | 7.35 |
| CHEMBL4094794 | — | — | 1 | 7.31 |
| CHEMBL4099236 | — | — | 1 | 7.28 |
| CHEMBL4081780 | — | — | 1 | 7.27 |
| CHEMBL4099798 | — | — | 1 | 7.25 |
| CHEMBL4071121 | — | — | 1 | 7.24 |
| CHEMBL4086944 | — | — | 1 | 7.18 |
| CHEMBL4079093 | — | — | 1 | 6.87 |
| CHEMBL4065510 | — | — | 1 | 6.83 |
| CHEMBL4060896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102620 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4092052 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4070196 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4069565 | — | EC50 | = | 13.7 | nM | 7.86 |
| CHEMBL4103339 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4072282 | — | EC50 | = | 21.5 | nM | 7.67 |
| CHEMBL4091498 | — | EC50 | = | 39.9 | nM | 7.40 |
| CHEMBL4071240 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4094794 | — | EC50 | = | 49.3 | nM | 7.31 |
| CHEMBL4099236 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4081780 | — | EC50 | = | 54.2 | nM | 7.27 |
| CHEMBL4099798 | — | EC50 | = | 56.4 | nM | 7.25 |
| CHEMBL4071121 | — | EC50 | = | 57.9 | nM | 7.24 |
| CHEMBL4086944 | — | EC50 | = | 66.2 | nM | 7.18 |
| CHEMBL4079093 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4065510 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4060896 | — | Activity | - | — | - |