Assay Detail
Binding
CHEMBL4008774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 6.10 |
| CHEMBL4083038 | — | — | 1 | 5.14 |
| CHEMBL4090002 | — | — | 1 | 5.12 |
| CHEMBL4086085 | — | — | 1 | 4.37 |
| CHEMBL4066708 | — | — | 1 | 4.25 |
| CHEMBL3906257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4083038 | — | IC50 | = | 7160.0 | nM | 5.14 |
| CHEMBL4090002 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4086085 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL4066708 | — | IC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL3906257 | — | IC50 | > | 100000.0 | nM | - |