Assay Detail
Functional
CHEMBL4008832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine/quinine/sulfadoxine-pyrimethamine/amodiaquine-resistant asexual blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green-based fluorometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.55 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081254 | — | — | 1 | 8.68 |
| CHEMBL4060939 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081254 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4060939 | — | EC50 | = | 3.83 | nM | 8.42 |