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Assay Detail

CHEMBL4008901

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against patient-derived SJH1 cells assessed as reduction in cell viability after 3 days by Alamar blue assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SJH1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma.
Zhou Q, Phoa AF, Abbassi RH, Hoque M, Reekie TA, Font JS, Ryan RM, Stringer BW, Day BW, Johns TG, Munoz L, Kassiou M.
J Med Chem (2017) 60 : 2052 -2070
PubMed 28206758 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 5.09 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4084605 1 5.66
CHEMBL4096575 1 5.50
CHEMBL3102950 1 5.39
CHEMBL4078550 1 5.29
CHEMBL4080994 1 5.28
CHEMBL4105239 1 5.24
CHEMBL4067661 1 4.55
CHEMBL4065701 1 4.52
CHEMBL4088888 1 4.38
CHEMBL4070354 1 -
CHEMBL4097535 1 -
CHEMBL4087125 1 -
CHEMBL4083661 1 -
CHEMBL4075959 1 -
CHEMBL4092345 1 -
CHEMBL4102553 1 -
CHEMBL4073972 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4084605 EC50 = 2200.0 nM 5.66
CHEMBL4096575 EC50 = 3200.0 nM 5.50
CHEMBL3102950 EC50 = 4100.0 nM 5.39
CHEMBL4078550 EC50 = 5100.0 nM 5.29
CHEMBL4080994 EC50 = 5200.0 nM 5.28
CHEMBL4105239 EC50 = 5700.0 nM 5.24
CHEMBL4067661 EC50 = 28000.0 nM 4.55
CHEMBL4065701 EC50 = 30000.0 nM 4.52
CHEMBL4088888 EC50 = 42000.0 nM 4.38
CHEMBL4070354 EC50 > 50000.0 nM -
CHEMBL4097535 EC50 > 50000.0 nM -
CHEMBL4087125 EC50 > 50000.0 nM -
CHEMBL4083661 EC50 > 50000.0 nM -
CHEMBL4075959 EC50 > 50000.0 nM -
CHEMBL4092345 EC50 > 50000.0 nM -
CHEMBL4102553 EC50 > 50000.0 nM -
CHEMBL4073972 EC50 > 50000.0 nM -