Assay Detail
Binding
CHEMBL4009330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of BTN3A1 in human Vgamma9Vdelta2 T cells assessed as induction of T effector cells mediated K562 cell lysis preincubated with K562 cells for 2 hrs followed by T effector cell addition measured after 4 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Butyrophilin subfamily 3 member A1 (CHEMBL4105758) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.22 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145233 | — | — | 1 | 8.80 |
| CHEMBL4061531 | — | — | 1 | 6.55 |
| CHEMBL4081059 | — | — | 1 | 5.14 |
| CHEMBL4089656 | — | — | 1 | 4.39 |
| CHEMBL4097373 | — | — | 1 | - |
| CHEMBL4099094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145233 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4061531 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4081059 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4089656 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4097373 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4099094 | — | EC50 | > | 100000.0 | nM | - |