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Assay Detail

CHEMBL4009370

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Functional
Anti-HCV activity against Hepatitis C virus genotype 1b infected in human Huh7 replicon cells after 96 hrs by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.
Tichý M, Smoleń S, Tloušt'ová E, Pohl R, Oždian T, Hejtmánková K, Lišková B, Gurská S, Džubák P, Hajdúch M, Hocek M.
J Med Chem (2017) 60 : 2411 -2424
PubMed 28221790 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.13 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4071458 1 7.22
CHEMBL4105294 1 6.96
CHEMBL4100457 1 6.89
CHEMBL4073630 1 6.64
CHEMBL4078608 1 6.33
CHEMBL4096628 1 6.02
CHEMBL562967 MERICITABINE 2.0 1 5.92
CHEMBL4092250 1 5.69
CHEMBL4081046 1 5.68
CHEMBL4097585 1 5.30
CHEMBL4092731 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4071458 EC50 = 60.0 nM 7.22
CHEMBL4105294 EC50 = 110.0 nM 6.96
CHEMBL4100457 EC50 = 130.0 nM 6.89
CHEMBL4073630 EC50 = 230.0 nM 6.64
CHEMBL4078608 EC50 = 470.0 nM 6.33
CHEMBL4096628 EC50 = 950.0 nM 6.02
CHEMBL562967 MERICITABINE EC50 = 1200.0 nM 5.92
CHEMBL4092250 EC50 = 2050.0 nM 5.69
CHEMBL4081046 EC50 = 2100.0 nM 5.68
CHEMBL4097585 EC50 = 5020.0 nM 5.30
CHEMBL4092731 EC50 = 17520.0 nM 4.76