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Assay Detail

CHEMBL4009381

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.
Tichý M, Smoleń S, Tloušt'ová E, Pohl R, Oždian T, Hejtmánková K, Lišková B, Gurská S, Džubák P, Hajdúch M, Hocek M.
J Med Chem (2017) 60 : 2411 -2424
PubMed 28221790 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.17 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4096628 1 6.82
CHEMBL4078608 1 6.44
CHEMBL4105294 1 6.36
CHEMBL4071458 1 6.33
CHEMBL4084001 1 6.27
CHEMBL4097585 1 6.25
CHEMBL4100457 1 6.17
CHEMBL4062283 1 6.11
CHEMBL4073630 1 5.88
CHEMBL4092731 1 5.84
CHEMBL4081046 1 5.37
CHEMBL4088933 1 -
CHEMBL888 GEMCITABINE 4.0 1 -
CHEMBL4065049 1 -
CHEMBL4092250 1 -
CHEMBL4067712 1 -
CHEMBL4069820 1 -
CHEMBL4070411 1 -
CHEMBL4090817 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4096628 IC50 = 150.0 nM 6.82
CHEMBL4078608 IC50 = 360.0 nM 6.44
CHEMBL4105294 IC50 = 440.0 nM 6.36
CHEMBL4071458 IC50 = 470.0 nM 6.33
CHEMBL4084001 IC50 = 540.0 nM 6.27
CHEMBL4097585 IC50 = 560.0 nM 6.25
CHEMBL4100457 IC50 = 680.0 nM 6.17
CHEMBL4062283 IC50 = 770.0 nM 6.11
CHEMBL4073630 IC50 = 1330.0 nM 5.88
CHEMBL4092731 IC50 = 1460.0 nM 5.84
CHEMBL4081046 IC50 = 4280.0 nM 5.37
CHEMBL4088933 IC50 > 50000.0 nM -
CHEMBL888 GEMCITABINE IC50 - -
CHEMBL4065049 IC50 > 50000.0 nM -
CHEMBL4092250 IC50 > 50000.0 nM -
CHEMBL4067712 IC50 > 50000.0 nM -
CHEMBL4069820 IC50 > 50000.0 nM -
CHEMBL4070411 IC50 > 50000.0 nM -
CHEMBL4090817 IC50 > 50000.0 nM -