Assay Detail
Functional
CHEMBL4009673
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Antiproliferative activity against human Kelly cells after 72 hrs by CCK8 assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Kelly |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.54 | 7.24 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099635 | — | — | 2 | 7.24 |
| CHEMBL121556 | — | — | 2 | 6.54 |
| CHEMBL4092859 | — | — | 2 | 5.85 |
| CHEMBL13960 | DICHLOROACETIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099635 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL121556 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4092859 | — | IC50 | = | 1426.0 | nM | 5.85 |
| CHEMBL13960 | DICHLOROACETIC ACID | IC50 | = | 11095000.0 | nM | - |
| CHEMBL121556 | — | Activity | - | — | - | |
| CHEMBL4092859 | — | Activity | - | — | - | |
| CHEMBL4099635 | — | Activity | - | — | - |