Assay Detail
Binding
CHEMBL4009730
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Binding affinity to human C-terminal His6-tagged SPHK1 S225A mutant expressed in fall armyworm sf9 cells after 1 hr by ITC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.23 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082814 | — | — | 1 | 5.54 |
| CHEMBL4067356 | — | — | 1 | 4.92 |
| CHEMBL4088607 | — | — | 1 | - |
| CHEMBL4064624 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082814 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL4067356 | — | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL4088607 | — | Kd | - | — | - | |
| CHEMBL4064624 | — | Kd | - | — | - |