Assay Detail
Binding
CHEMBL4009735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 mins followed by enzyme addition by pGAPase coupled fluorometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminyl-peptide cyclotransferase (CHEMBL4105900) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.79 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097599 | — | — | 1 | 7.90 |
| CHEMBL566563 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097599 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL566563 | — | IC50 | = | 21.5 | nM | 7.67 |