Assay Detail
Functional
CHEMBL4009781
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Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.84 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091820 | — | — | 1 | 7.70 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.30 |
| CHEMBL4062346 | — | — | 1 | 7.30 |
| CHEMBL4085248 | — | — | 1 | 6.66 |
| CHEMBL4070976 | — | — | 1 | 5.96 |
| CHEMBL4093332 | — | — | 1 | 5.92 |
| CHEMBL4089423 | — | — | 1 | 5.82 |
| CHEMBL4101069 | — | — | 1 | 5.72 |
| CHEMBL4083096 | — | — | 1 | 5.68 |
| CHEMBL4099562 | — | — | 1 | 5.64 |
| CHEMBL4081558 | — | — | 1 | 5.57 |
| CHEMBL4084062 | — | — | 1 | 5.55 |
| CHEMBL4095235 | — | — | 1 | 5.51 |
| CHEMBL4061268 | — | — | 1 | 5.48 |
| CHEMBL4074775 | — | — | 1 | 5.30 |
| CHEMBL4102004 | — | — | 1 | 5.28 |
| CHEMBL4077736 | — | — | 1 | 5.23 |
| CHEMBL4074759 | — | — | 1 | 5.15 |
| CHEMBL4088635 | — | — | 1 | 5.11 |
| CHEMBL4097280 | — | — | 1 | 4.94 |
| CHEMBL4072621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091820 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4062346 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4085248 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4070976 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4093332 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4089423 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4101069 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4083096 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4099562 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4081558 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4084062 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4095235 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4061268 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4074775 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4102004 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4077736 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4074759 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4088635 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4097280 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4072621 | — | IC50 | > | 40000.0 | nM | - |