Assay Detail
Functional
CHEMBL4009784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U87 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.20 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.72 |
| CHEMBL4089423 | — | — | 1 | 5.58 |
| CHEMBL4095235 | — | — | 1 | 5.37 |
| CHEMBL4061268 | — | — | 1 | 5.31 |
| CHEMBL4077736 | — | — | 1 | 5.29 |
| CHEMBL4074759 | — | — | 1 | 5.29 |
| CHEMBL4070976 | — | — | 1 | 5.24 |
| CHEMBL4091820 | — | — | 1 | 5.13 |
| CHEMBL4088635 | — | — | 1 | 5.10 |
| CHEMBL4081558 | — | — | 1 | 5.10 |
| CHEMBL4102004 | — | — | 1 | 5.08 |
| CHEMBL4097280 | — | — | 1 | 5.00 |
| CHEMBL4093332 | — | — | 1 | 4.97 |
| CHEMBL4084062 | — | — | 1 | 4.96 |
| CHEMBL4099562 | — | — | 1 | 4.93 |
| CHEMBL4074775 | — | — | 1 | 4.89 |
| CHEMBL4062346 | — | — | 1 | 4.87 |
| CHEMBL4085248 | — | — | 1 | 4.70 |
| CHEMBL4072621 | — | — | 1 | - |
| CHEMBL4083096 | — | — | 1 | - |
| CHEMBL4101069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4089423 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4095235 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4061268 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4077736 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4074759 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4070976 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4091820 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4088635 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4081558 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4102004 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4097280 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4093332 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4084062 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4099562 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4074775 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4062346 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4085248 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4072621 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4083096 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4101069 | — | IC50 | > | 40000.0 | nM | - |