Assay Detail
Functional
CHEMBL4009785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H460 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 8.00 |
| CHEMBL4062346 | — | — | 1 | 6.33 |
| CHEMBL4070976 | — | — | 1 | 6.19 |
| CHEMBL4091820 | — | — | 1 | 6.17 |
| CHEMBL4085248 | — | — | 1 | 6.00 |
| CHEMBL4089423 | — | — | 1 | 5.70 |
| CHEMBL4099562 | — | — | 1 | 5.66 |
| CHEMBL4077736 | — | — | 1 | 5.55 |
| CHEMBL4095235 | — | — | 1 | 5.54 |
| CHEMBL4061268 | — | — | 1 | 5.52 |
| CHEMBL4102004 | — | — | 1 | 5.43 |
| CHEMBL4081558 | — | — | 1 | 5.38 |
| CHEMBL4074775 | — | — | 1 | 5.17 |
| CHEMBL4093332 | — | — | 1 | 5.14 |
| CHEMBL4084062 | — | — | 1 | 4.68 |
| CHEMBL4074759 | — | — | 1 | - |
| CHEMBL4072621 | — | — | 1 | - |
| CHEMBL4083096 | — | — | 1 | - |
| CHEMBL4101069 | — | — | 1 | - |
| CHEMBL4097280 | — | — | 1 | - |
| CHEMBL4088635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4062346 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4070976 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4091820 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4085248 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4089423 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4099562 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4077736 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4095235 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4061268 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4102004 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4081558 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4074775 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4093332 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4084062 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4074759 | — | IC50 | - | — | - | |
| CHEMBL4072621 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4083096 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4101069 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4097280 | — | IC50 | - | — | - | |
| CHEMBL4088635 | — | IC50 | - | — | - |